Revvity HTRF Human Total BRD4 Detection Kit

Revvity BRD4 is a transcriptional regulator involved in embryogenesis and cancer development. Like the other members of the Bromodomains and Extraterminal (BET) family (BRD2, BRD3, and BRDT), BRD4 comprises two bromodomains which bind acetylated lysine residues on proteins, such as histones. Associated with Cyclin T1 and CDK9, the three proteins form a multiprotein complex called P-TEFb, and control gene transcription. As well as its role in transcriptional control, BRD4 is involved in DNA damage response. Inhibition of BRD4 function is part of the strategy for cancer treatments. More recently, targeting BRD4 degradation via PROTAC molecules has emerged as a novel and promising therapeutic approach. - PEGSK (Additional S&H or Hazmat Fees May Apply)