| Description | |
|---|---|
| Catalogue Number | MAIPNTR10 |
| Trade Name |
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| Description | MultiScreen IP Filter Plate, 0.45 µM, clear, non-sterile |
| Background Information | Increasing drug candidate predictability earlier in the discovery pipeline using non-cell-based assays can improve candidate throughput during the ADME stage. Non-cell-based permeability assays are predictive models for oral absorption of development candidates. MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport. Membranes have uniform pore structure and density for reliable transport: - Individual wells minimize candidate cross-talk - Compatibility with automated liquid handling systems increases throughput Permeability Assay: - The MultiScreen Permeability plate has a polycarbonate membrane, which supports a hexane/hexadecane artificial layer for permeability assays.1 PAMPA Assay: - The MultiScreen-IP plate has a hydrophobic PVDF membrane, which supports a lipid bilayer for PAMPA asays.2,3 MultiScreen Acceptor Plate: - The MultiScreen Acceptor plate can be used with either plate to capture passively transported compounds. Constructed of 100% PTFE, the plate can improve LC/MS results depending on the charge of the small molecules being evaluated. |
| Product Information | |
|---|---|
| Automation Compatible | No |
| Filter Code | IP |
| Color Code | Clear |
| Number of Wells | 96 |
| Quality Level | MQ400 |
| Applications | |
|---|---|
| Application | This clear 96 well filter plate has a Hydrophobic PVDF membrane used for PAMPA. |
| Key Applications |
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| Biological Information | |
|---|---|
| Media | Immobilon®-P |
| Sterility | Non-Sterile |
| Physicochemical Information | |
|---|---|
| Pore Size | 0.45 µM |
| Dimensions | |
|---|---|
| Volume | 50 µL–250 µL |
| Materials Information | |
|---|---|
| Chemistry |
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| Device Material |
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| Packaging Information | |
|---|---|
| Material Size | 10 |