Cayman Tp Receptor (Mouse) Blocking Peptide; Size- 200 Micrograms

To be used in conjunction with Cayman’s TP receptor (mouse) Polyclonal Antibody (Item No. ) to block protein-antibody complex formation during analysis for the TP receptor Thromboxane A₂ (TXA₂) is a potent vasoconstrictor and activator of platelet aggregation. The short half-life of TXA₂ ensures local action whether generated by vascular endothelial cells or by platelets and confers physiologically beneficial or deleterious effects under inflammatory situations.^, TXA₂ elicits its effects via a 7-transmembrane domain G-protein coupled receptor, the TP receptor. This receptor can also bind prostaglandin H₂ and isoprostanes and was first cloned from human placenta and the platelet-like MEG-01 cell line.^, The TP receptor is highly expressed in platelets and is relatively less abundant in tissues such as lung, kidney, brain, spleen, thymus, monocytes, uterus, and placenta.^,,, The apparent molecular weight for TP receptors has been reported from 37 to 70 kDa, depending on different degrees of glycosylation,^,, however Cayman’s antibody consistently detects the TP receptor at 55 and 64 kDa in platelet, kidney and COS-7 cell samples.

WARNING This product is not for human or veterinary use.