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Cayman PTEN Polyclonal Antibody
List Price $347.00 Your Price $347.00
Cayman PTEN Polyclonal Antibody - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10005059-1
MFG.PART: 10005059-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Phosphatase and tensin homolog (PTEN) is a tumor suppressor with roles in cell division, cell migration, and apoptosis.,,, It is ubiquitously expressed and localized to the cytosol and nucleus where it dephosphorylates phosphatidylinositol-(3,4,5)-triphosphate (PIP3) to phosphatidylinositol-(3,4)-diphosphate (PIP2) to antagonize PI3K signaling and regulates spliceosome assembly and pre-mRNA splicing, respectively. PTEN inhibits cell cycle progression and induces apoptosis, as well as inhibits cell adhesion and migration in vitro. PTEN deletions have been found in various cancers, including glioblastomas and prostate, breast, and kidney cells. Germline mutations in PTEN induce a variety of syndromes, including Cowden, Bannayan-Riley-Ruvalcaba, Proteus, and Proteus-like syndromes, that are characterized by increased risk of cancers, developmental delays, autism spectrum disorders, and macroencephaly. Cayman’s PTEN Polyclonal antibody can be used for Western blot applications.
WARNING This product is not for human or veterinary use.
Technical Information
Synonyms
- Mutated in Multiple Advanced Cancers 1
- MMAC1
- Phosphatidylinositol-(3,4,5)-Triphosphate 3-Phosphatase and Dual-specificity Protein Phosphatase
- TEP1
Immunogen
Peptide from the internal region of human PTEN
Formulation
500 µl of peptide affinity-purified polyclonal antibody
Storage Buffer
TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide
Host
Rabbit
Applications
WB
Cross Reactivity
- (+) PTEN
License
Sold under license from Millipore
UniProt Accession №
P60484
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 3 years
| SKU | CAYM-10005059-1 |
|---|---|
| Supplier Part Number | 10005059-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| Energy Star | No |
| Green | No |
| Controlled | N |