We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman CAY10441
List Price $1,008.00 Your Price $1,008.00
Cayman CAY10441 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10005186-50
MFG.PART: 10005186-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CAY10441 is an antagonist of the IP receptor.1 It is selective for the IP receptor over the prostaglandin E2 (PGE2) receptor subtypes EP1, EP2, EP3, and EP4, the FP and TP receptors, and a panel of 30 other receptors and ion channels but does bind to the α2A-adrenergic and imidazoline I2 receptors. CAY10441 inhibits carbaprostacyclin-induced cAMP accumulation in SH-SY5Y cells (pKB = 8.8) and vasorelaxation of isolated human pulmonary arteries induced by the IP receptor agonist cicaprost (Item No. 16831; PA2 = 8.2).1,2 It also decreases cicaprost-induced inhibition of platelet aggregation in human platelet-rich plasma.2 CAY10441 reduces acetic acid-induced writhing and carrageenan-induced paw hyperalgesia in rats (ED50s = 4 and 2.8 mg/kg, respectively).1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4,5-
CAS Number
221529-58-4
Synonyms
- Ro 1138452
Molecular Formula
C19H23N3O
Formula Weight
309.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2)(1:10): 0.05 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 20 mg/mL
λmax
232 nm
SMILES
CC(C)Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1
InChi Code
InChI=1S/C19H23N3O/c1-14(2)23-18-9-5-16(6-10-18)13-15-3-7-17(8-4-15)22-19-20-11-12-21-19/h3-10,14H,11-13H2,1-2H3,(H2,20,21,22)
InChi Key
GYYRMJMXXLJZAB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10005186-50 |
|---|---|
| Supplier Part Number | 10005186-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 221529-58-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |