Cayman LPA1 Blocking Peptide

To be used in conjunction with Cayman’s LPA₁ polyclonal antibody (Catalog No. ) to block protein-antibody complex formation during immunochemical analysis of LPA₁. · LPA₁ (also known as EDG-2) is one of four known LPA receptors (LPA_1-4). LPA_1-3 are part a family of g protein-coupled receptors that share identity to the sphingosine-1-phosphate receptors (S1P_1-5). LPA₁ couples with three types of g proteins, g_i/o, g_q, and g_12/13 to induce a range of cellular responses including activation of phospholipase C, multiple kinases, the serum response element, and cell proliferation.^, LPA₁ mRNA is detected in a wide range of tissues and cells including brain, heart, small intestine, spleen, testis, kidney, HeLa cells, and A549 cells.^, Murine and human LPA₁ have 364 amino acids with an estimated molecular weight of 41 kDa. Cayman’s LPA₁ polyclonal antibody detects the protein from several species at 43-50 kDa, suggesting heterogeneous LPA₁ post-translational modifications in distinct cells.

WARNING This product is not for human or veterinary use.