Cayman D-myo-Inositol-2,4,5-triphosphate (sodium salt)

The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals.^1,2 The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals.^1,2 The most studied InsP, D-myo-Inositol-2,4,5-triphosphate (sodium salt) (Ins(1,4,5)P₃), more commonly referred to as IP₃, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.^3,4 Binding of Ins(1,4,5)P₃ to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.^4,5 Ins(2,4,5)P₃ is a metabolically stable analog of Ins(1,4,5)P₃ that is commonly used to study Ca²⁺ signaling pathways. Ins(2,4,5)P₃ acts as a partial agonist at rat hepatic IP₃ receptors, exhibiting 65% of the maximal Ca²⁺ response obtained with Ins(1,4,5)P₃.⁶

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