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Cayman 18-hydroxy-11-deoxy Corticosterone
List Price $194.00 Your Price $194.00
Cayman 18-hydroxy-11-deoxy Corticosterone - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10007851-1
MFG.PART: 10007851-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland., Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; Item No. ) as well as angiotensin II (Item No. ), which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells., 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; Item No. ) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone (Item No. ) and can be converted to aldosterone (Item No. ) by the capsular portion of rat adrenal glands., Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
18,21-
CAS Number
379-68-0
Synonyms
- 18-Hydroxydeoxycorticosterone
- 18-OH-DOC
Molecular Formula
C21H30O4
Formula Weight
346.5
Formulation
A solid
Solubility
- DMF: 25 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 25 mg/mL
SMILES
O=C(CO)[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@@]21CO)=O
InChi Code
InChI=1S/C21H30O4/c1-20-8-6-14(24)10-13(20)2-3-15-16(20)7-9-21(12-23)17(15)4-5-18(21)19(25)11-22/h10,15-18,22-23H,2-9,11-12H2,1H3/t15-,16+,17+,18-,20+,21-/m1/s1
InChi Key
VPJHREHKRNIYDB-TZGXILGRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10007851-1 |
|---|---|
| Supplier Part Number | 10007851-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 379-68-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |