Cayman SPD-304

Tumor necrosis factor α (TNF-α) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.^,, TNF-α functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways.^, SPD-304 is an inhibitor of tumor necrosis factor α (TNF-α). that prevents binding to the TNF Receptor 1 (TNFR1) with an IC₅₀ of 22 µM. It binds to the biologically active TNF-α trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC₅₀ of 4.6 µM.

WARNING This product is not for human or veterinary use.