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Cayman Zafirlukast
List Price
$28.00
Your Price
$28.00
Cayman Zafirlukast - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-10008282-10
MFG.PART:
10008282-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Zafirlukast is a cysteinyl leukotriene 1 (CysLT1) receptor antagonist (IC50 = 0.014 μM in a cell-based calcium mobilization assay). It is selective for CysLT1 over CysLT2 receptors (IC50 = 58 μM). It inhibits mucus secretion induced by leukotriene D4 (LTD4; Item No. ) in isolated guinea pig trachea (IC50 = 0.6 μM). Zafirlukast (5 μM) inhibits ovalbumin-induced increases in tracheal mucus secretion in ovalbumin-sensitized guinea pigs by 65%. It inhibits LTD4-induced bronchoconstriction in anesthetized guinea pigs (ED50 = 61 nmol/kg, i.v.). Formulations containing zafirlukast have been used in the prophylaxis and chronic treatment of asthma.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[3-
CAS Number
107753-78-6
Molecular Formula
C31H33N3O6S
Formula Weight
575.7
Purity
≥97%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2) (1:1): .5 mg/mL
- DMSO: 20 mg/mL
- Ethanol: .25 mg/mL
λmax
203, 215, 241, 299 nm
SMILES
COc1cc(ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
InChi Code
InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)
InChi Key
YEEZWCHGZNKEEK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10008282-10 |
|---|---|
| Supplier Part Number | 10008282-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 107753-78-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |