Cayman PSN375963

GPR119 (previously designated SNORF25) is an orphan g protein-coupled receptor expressed predominantly in the pancreas and gastrointestinal tract in humans and in the brain, pancreas, and gastrointestinal tract in rodents. It mediates a reduction in food intake and body weight gain in rats upon treatment with oleoyl ethanolamide (OEA), an endogenous, potent agonist for PPARα.^, PSN375963 is a potent and selective agonist of GPR119 that shows similar potency to oleoyl ethanolamide (OEA) at both recombinant mouse and human GPR119 receptors, exhibiting EC₅₀ values of 8.4 and 7.9 µM, respectively (EC₅₀ values for OEA are 3.2 and 2.9 µM, respectively). These data suggest that PSN375963 may be useful as a therapeutic agent for the treatment of obesity.

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