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Cayman Resolvin E1-d4
List Price $224.00 Your Price $224.00
Cayman Resolvin E1-d4 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10009854-10
MFG.PART: 10009854-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Resolvin E1-d4 (RvE1-d4) is intended for use as an internal standard for the quantification of RvE1 (Item No. ) by GC- or LC-MS. RvE1 is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from eicosapentaenoic acid (EPA; Item No. | | ) via an 18-HEPE epoxide intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA and 5-lipoxygenase (5-LO), by leukotriene A4 (LTA4) hydrolase in human polymorphonuclear (PMN) neutrophils. RvE1 activates chemokine-like receptor 1 (CMKLR1; EC50 = 0.137 nM in a reporter assay). RvE1 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A (Item No. ). It increases survival and prevents decreases in colon length in a mouse model of TNBS-induced colitis when administered at a dose of 50 µg/kg. RvE1 (50 µg/kg) inhibits ovalbumin-induced increases in eosinophil and total cell numbers, as well as IL-13 and IgE levels in bronchoalveolar lavage fluid (BALF) in an ovalbumin-sensitized mouse model of asthma.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5S,12R,18R-
Synonyms
- RvE1-
d4 - 5S,12R,18R-trihydroxy-EPA-d4
- 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA-d4
- 5,12,18R-triHEPE-d4
Molecular Formula
C20H26D4O5
Formula Weight
354.5
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solution in ethanol
Solubility
- DMF: 50 mg/mL
- Ethanol: 50 mg/mL
- PBS (pH 7.2): 0.05 mg/mL
λmax
272 nm
SMILES
CC[C@@H](O)/C=C/C([2H])=C([2H])\C[C@@H](O)/C=C/C=C/C([2H])=C([2H])\[C@@H](O)CCCC(O)=O
InChi Code
InChI=1S/C20H30O5/c1-2-17(21)11-8-5-9-14-18(22)12-6-3-4-7-13-19(23)15-10-16-20(24)25/h3-9,11-13,17-19,21-23H,2,10,14-16H2,1H3,(H,24,25)/b4-3+,9-5-,11-8+,12-6+,13-7-/t17-,18+,19-/m1/s1/i5D,7D,9D,13D
InChi Key
AOPOCGPBAIARAV-VUOMCXAQSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Stability
≥ 1 year
| SKU | CAYM-10009854-10 |
|---|---|
| Supplier Part Number | 10009854-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -80 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| Energy Star | No |
| Green | No |
| Controlled | N |