Cayman NS 304

Prostaglandin I₂ (PGI₂) is a potent vasorelaxant and inhibitor of human platelet aggregation that mediates its actions by binding to a specific g protein-coupled receptor, the IP receptor, on the surface of endothelial cells and platelets.¹ The IP receptor also participates in signal transduction of the pain response, cardioprotection, and inflammation.^2,3,4,5,6 NS 304 is a prodrug of the active form of MRE-269, which is a potent and selective agonist for the human IP receptor with a K_i value of 20 nM.⁷ In contrast to prostaglandin I₂, which has a half-life of 30 seconds to a few minutes in vivo, NS 304 is long-acting. Plasma concentrations of MRE-269 remain near peak levels for more than eight hours in rats and dogs after NS 304 was administered orally.⁷

WARNING This product is not for human or veterinary use.