Cayman PIK-90

PIK-90 is a potent and cell permeable phosphoinositide 3-kinase (PI3K) inhibitor (IC₅₀ = 11, 350, 18, and 58 nM for p110 subunit isoforms α, β, γ, and δ, respectively). Through this action, PIK-90 reduces chemotaxis and induces apoptosis in chronic lymphocytic leukemia B cells. It also blocks proliferation of glioma cells in vitro. By inhibiting P110α, PIK-90 blocks insulin-stimulated phosphorylation of Akt in L1 adipocytes and L6 myotubes, preventing activation of the mTORC1 pathway.

WARNING This product is not for human or veterinary use.