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Cayman Sc-51089; Purity- Greater Than Or Equal To 95%; Size- 10 M
List Price
$113.00
Your Price
$113.00
Cayman Sc-51089; Purity- Greater Than Or Equal To 95%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-10011561-10
MFG.PART:
10011561-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P (SPD-D) is an analog of substance P (Item No. ) and a broad-spectrum neuropeptide antagonist with anticancer activity. It blocks intracellular calcium increases induced by vasopressin, bradykinin (Item No. ), gastrin (Item No. ), and galanin (Item No. ) in H-510 small cell lung carcinoma (SCLC) cells. SPD-D also blocks vasopressin- and bradykinin-induced MAPK signaling in H-510 SCLC cells in a concentration-dependent manner. It inhibits DNA synthesis in a panel of cancer cell lines (IC50s = 20-50 μM) and reduces colony formation of HC12, ICR-SC112, HX149, and NCI-H226 cancer cells in vitro (IC50s = 0.5-6.5 μM). In vivo, SPD-D (2.1 μg, s.c.) inhibits tumor growth in HC12 and ICR-SC112 SCLC mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
D-arginyl-L-
Synonyms
- D-Phe5SP
- L-756,867
- SPD-D
Molecular Formula
C79H109N19O12 • XCF3COOH
Formula Weight
1516.8
Purity
≥95%
Formulation
A lyophilized powder
Solubility
- Water: 1 mg/ml
SMILES
O=C(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](CCC(N)=O)C(N[C@H](CC3=CNC4=C3C=CC=C4)C(N[C@H](C(N[C@H](CC5=CNC6=C5C=CC=C6)C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)CC(C)C)=O)=O)CC7=CC=CC=C7)=O)=O)=O)=O)=O)[C@H]8N(C([C@H](N)CCCNC(N)=N)=O)CCC8.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C79H109N19O12.C2HF3O2/c1-46(2)38-59(68(83)100)91-70(102)60(39-47(3)4)92-73(105)64(43-51-45-88-56-28-14-12-25-53(51)56)95-72(104)61(40-48-20-7-5-8-21-48)93-74(106)63(42-50-44-87-55-27-13-11-24-52(50)55)94-69(101)57(32-33-67(82)99)89-71(103)62(41-49-22-9-6-10-23-49)96-76(108)66-31-19-37-98(66)78(110)58(29-15-16-34-80)90-75(107)65-30-18-36-97(65)77(109)54(81)26-17-35-86-79(84)85;3-2(4,5)1(6)7/h5-14,20-25,27-28,44-47,54,57-66,87-88H,15-19,26,29-43,80-81H2,1-4H3,(H2,82,99)(H2,83,100)(H,89,103)(H,90,107)(H,91,102)(H,92,105)(H,93,106)(H,94,101)(H,95,104)(H,96,108)(H4,84,85,86);(H,6,7)/t54-,57+,58+,59+,60+,61+,62-,63-,64-,65+,66+;/m1./s1
InChi Key
LDPZJUMVCRKMNL-YJEREJMLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10011561-10 |
|---|---|
| Featured | No |
| Supplier Part Number | 10011561-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | Y |
| CAS Number | 146033-02-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |