Cayman TP Receptor (human) Polyclonal FITC Antibody

Thromboxane A₂ (TXA₂) is a potent vasoconstrictor and activator of platelet aggregation. The short half-life of TXA₂ ensures local action whether generated by vascular endothelial cells or by platelets and confers physiologically beneficial or deleterious effects under inflammatory situations.^, TXA₂ elicits its effects via a 7-transmembrane domain G protein-coupled receptor, the TP receptor. This receptor can also bind prostaglandin H₂ and isoprostanes and was first cloned from human placenta and the platelet-like MEG-01 cell line.^, The TP receptor is highly expressed in platelets and is relatively less abundant in tissues such as lung, kidney, brain, spleen, thymus, monocytes, uterus, and placenta.^,,,,,

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