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Cayman Eeyarestatin 1
List Price
$116.00
Your Price
$116.00
Cayman Eeyarestatin 1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-10012609-10
MFG.PART:
10012609-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Terminally misfolded proteins, recognized by chaperones on the endoplasmic reticulum (ER), are transported to depots for ubiquitination and proteasomal degradation by the ER-associated protein degradation (ERAD) pathway. Eeyarestatin 1 is an inhibitor of the ERAD pathway, blocking the degradation of misfolded proteins at a dose of 8 µM. It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3., Eeyarestatin 1, at 4 µM, interferes with both retrograde and anterograde trafficking of proteins, including certain toxins, and potentially, viruses.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl] hydroxyamino]-5,5-dimethyl-2-oxo-1- imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
CAS Number
412960-54-4
Molecular Formula
C27H25Cl2N7O7
Formula Weight
630.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
λmax
245, 285, 380 nm
SMILES
O=C1N(CC(N/N=C/C=C/C2=CC=C([N+]([O-])=O)O2)=O)C(C)(C)C(N(C(NC3=CC=C(Cl)C=C3)=O)O)N1C4=CC=C(Cl)C=C4
InChi Code
InChI=1S/C27H25Cl2N7O7/c1-27(2)24(35(40)25(38)31-19-9-5-17(28)6-10-19)34(20-11-7-18(29)8-12-20)26(39)33(27)16-22(37)32-30-15-3-4-21-13-14-23(43-21)36(41)42/h3-15,24,40H,16H2,1-2H3,(H,31,38)(H,32,37)/b4-3+,30-15+
InChi Key
JTUXTPWYZXWOIB-LWWHHIEBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10012609-10 |
|---|---|
| Supplier Part Number | 10012609-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 412960-54-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |