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Cayman MK-571
List Price $587.00 Your Price $587.00
Cayman MK-571 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10029-50
MFG.PART: 10029-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
MK-571 is a cysteinyl leukotriene 1 (CysLT1) receptor antagonist (Ki = 2.1 nM in a radioligand binding assay using isolated human lung membranes).1 It inhibits contractions induced by leukotriene D4 (LTD4; Item No. 20310) or LTE4 (Item No. 20410) in histamine-primed isolated guinea pig trachea (PA2s = 9.4 and 9.1, respectively), but does not inhibit contractions induced by LTC4 (Item No. 20210) in histamine-primed isolated guinea pig trachea when used at a concentration of 190 nM. MK-571 (100 nM) inhibits LTD4-induced calcium mobilization in COS-7 monkey kidney cells expressing the human CysLT1 receptor in a reporter assay.2 MK-571 (5 mg/kg) improves tissue damping and elasticity, markers of lung function, and decreases IL-4 and IL-5 levels in bronchoalveolar lavage fluid (BALF) in a mouse model of ovalbumin-induced asthma.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[[[3-[(1E)-
CAS Number
115104-28-4
Synonyms
- L-660,711
Molecular Formula
C26H27ClN2O3S2
Formula Weight
515.1
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 1 mg/mL
λmax
226, 283, 327, 344, 357 nm
SMILES
ClC1=CC=C2C(N=C(/C=C/C3=CC=CC(C(SCCC(O)=O)SCCC(N(C)C)=O)=C3)C=C2)=C1
InChi Code
InChI=1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+
InChi Key
AXUZQJFHDNNPFG-UXBLZVDNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10029-50 |
|---|---|
| Supplier Part Number | 10029-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 115104-28-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |