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Cayman PGPC
List Price $61.00 Your Price $61.00
Cayman PGPC - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10044-1
MFG.PART: 10044-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PGPC is an oxidized phospholipid that can be formed under conditions of oxidative stress. It is found as a component in mildly oxidized LDL (mm-LDL) and in products formed from the oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (Ox-PAPC). PGPC activates peroxisome proliferator-activated receptor (PPARα) in a concentration-dependent manner in a cell-based ligand-binding assay. It increases VCAM1 and E-selectin expression in human aortic endothelial cells (HAECs), as well as HAEC binding by monocytes and polymorphonuclear neutrophils (PMNs), in a concentration-dependent manner. PGPC (37.5 μM) also increases total 5-lipoxygenase metabolites in murine resident peritoneal macrophages (RPMs) and induces apoptosis in A7r5 rat aortic smooth muscle cells in vitro when used at a concentration of 50 μM., PGPC levels are increased in the serum, LDL, and peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease. UVA irradiation increases PGPC levels in cultured human skin fibroblasts.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-
CAS Number
89947-79-5
Synonyms
- 1-Hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine
- 1-Palmitoyl-2-glutaryl phosphatidylcholine
- 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine
Molecular Formula
C29H56NO10P
Formula Weight
609.7
Purity
≥98%
Formulation
A solution in ethanol
Solubility
- DMSO: 1 mg/mL
- Ethanol: 20 mg/mL
- PBS (pH 7.2): 5 mg/mL
SMILES
CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCC[N](C)(C)C)OC(=O)CCCC(=O)O
InChi Code
InChI=1S/C29H56NO10P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-28(33)37-24-26(40-29(34)21-18-19-27(31)32)25-39-41(35,36)38-23-22-30(2,3)4/h26H,5-25H2,1-4H3,(H-,31,32,35,36)/t26-/m1/s1
InChi Key
CDZVJFRXJAUXPP-AREMUKBSSA-N
Side Chain Carbon Sum
21:0
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-10044-1 |
|---|---|
| Supplier Part Number | 10044-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 89947-79-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |