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Cayman SC-57461A
List Price $186.00 Your Price $186.00
Cayman SC-57461A - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10108-10
MFG.PART: 10108-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Item No. 20110) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro.1,2 SC-57461A is a potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM).3,4 It blocks both the hydrolase and aminopeptidase activity in vitro.4 SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB4 biosynthesis without affecting LTC4 (Item No. 20210) or 6-keto prostaglandin F1α production (Item No. 15210).5 Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-methyl-
CAS Number
423169-68-0
Molecular Formula
C20H25NO3 • HCl
Formula Weight
363.9
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 3 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 3 mg/mL
- Ethanol: 0.25 mg/mL
λmax
266, 277 nm
SMILES
CN(CCC(O)=O)CCCOC(C=C1)=CC=C1CC2=CC=CC=C2.Cl
InChi Code
InChI=1S/C20H25NO3.ClH/c1-21(14-12-20(22)23)13-5-15-24-19-10-8-18(9-11-19)16-17-6-3-2-4-7-17;/h2-4,6-11H,5,12-16H2,1H3,(H,22,23);1H
InChi Key
SBBJJLDNKNNWFJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10108-10 |
|---|---|
| Supplier Part Number | 10108-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United Kingdom |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 423169-68-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |