Cayman N-Oleoyl Dopamine; Purity- Greater Than Or Equal To 98%; S

N-Oleoyl dopamine (ODA) is a selective, endogenous vanilloid receptor 1 (VR1) agonist isolated from bovine brain.¹ Structurally, it is the amide of oleic acid and dopamine and is therefore a “hybrid” analog which incorporates components of both the anandamide-like and dopamine neurotransmitter pathways. ODA binds to the human recombinant VR1 with a K_i of 36 nM making it equipotent to capsaicin and slightly more potent than N-arachidonoyl dopamine in this assay.¹ It causes hyperalgesia and nocifensive behavior that is blocked by the VR1 antagonist iodo-resiniferatoxin. ODA is selective for VR1 based on observations that it has weak affinity for the rat CB₁ receptor (K_i of 1.6 µM) and is a very weak inhibitor of FAAH. ODA is also a potent inhibitor of 5-lipoxygenase from rat basophilic leukemia-1 (RBL-1) cells, with a IC₅₀ of 7.5 nM.^2,3

WARNING This product is not for human or veterinary use.