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Cayman Misoprostol-d5
List Price $329.00 Your Price $329.00
Cayman Misoprostol-d5 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10216-1
MFG.PART: 10216-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Misoprostol-d5 is intended for use as an internal standard for the quantification of misoprostol (Item No. ) by GC- or LC-MS. Misoprostol is an analog of prostaglandin E1 (PGE1; Item No. ) and an agonist of the PGE2 receptor subtypes EP2 and EP3.,, It binds to EP1, EP2, EP3-III, and EP4 receptors (Kis = 35.675, 10.249, 0.319, 5.499 μM, respectively) and is selective for EP receptors over DP, FP, IP, and TP receptors (Kis = >100 μM for all). Misoprostol inhibits electrically induced twitch contraction in isolated guinea pig ileum circular muscle and vas deferens (EC50s = 102.92 and 4.3 nM, respectively), which endogenously express high levels of EP2 and EP3 receptors, respectively., It inhibits FMLP-induced superoxide anion generation in human neutrophils (EC50 = 0.35 μM). Misoprostol inhibits ethanol-induced gastric lesion formation in rats (ED50 = 0.31 μg/kg). Formulations containing misoprostol have been used in the prevention of NSAID-induced gastric ulcers.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
methyl 7-((1R,
Molecular Formula
C22H33D5O5
Formula Weight
387.6
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solution in methyl acetate
Solubility
- DMF: 100 mg/mL
- DMSO: 50 mg/mL
- Ethanol: 50 mg/mL
- PBS (pH 7.2): 1.6 mg/mL
SMILES
CCCC([2H])([2H])C(O)(C([2H])([2H])[2H])C/C=C/[C@H]([C@H]1CCCCCCC(OC)=O)[C@H](O)CC1=O
InChi Code
InChI=1S/C22H38O5/c1-4-5-14-22(2,26)15-10-12-18-17(19(23)16-20(18)24)11-8-6-7-9-13-21(25)27-3/h10,12,17-18,20,24,26H,4-9,11,13-16H2,1-3H3/b12-10+/t17-,18-,20-,22?/m1/s1/i2D3,14D2
InChi Key
OJLOPKGSLYJEMD-ZHGGQIFTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-10216-1 |
|---|---|
| Supplier Part Number | 10216-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| Energy Star | No |
| Green | No |
| Controlled | N |