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Cayman 8-ISO Prostaglandin A2
List Price $110.00 Your Price $110.00
Cayman 8-ISO Prostaglandin A2 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10235-500
MFG.PART: 10235-500
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
8-ISO Prostaglandin A2 (8-ISO PGA2) is an isoprostane. It is produced by the non-enzymatic oxidation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).1,2 8-ISO PGA2 (100 µM) induces calcium influx in HEK293 cells expressing human transient receptor potential ankyrin 1 (TRPA1) and isolated mouse trigeminal neurons.3 It potentiates glutamate-induced cytotoxicity and decreases glutathione (GSH) levels in HT22 hippocampal cells when used at concentrations of 1 and 30 µM, respectively.4 8-ISO PGA2 (10 µM) inhibits VEGF-induced migration and tube formation of human coronary artery endothelial cells, an effect that can be reversed by the TP receptor antagonist SQ 29,548 (Item No. 19025).5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(8β)-15S-
CAS Number
474391-66-7
Synonyms
- A2 Isoprostane
- 15-A2t-IsoP
- 15-A2t-Isoprostane
- 8-epi PGA2
- 8-ISO PGA2
Molecular Formula
C20H30O4
Formula Weight
334.5
Purity
≥98%
Limit of Detection
Formulation(Request formulation change)
A solution in methyl acetate
Solubility(Learn about Variance in Solubility)
- DMF: >75 mg/mL
- DMSO: >50 mg/mL
- Ethanol: >100 mg/mL
- PBS pH 7.2: >2.4 mg/mL
λmax
217 nm
SMILES
O=C1[C@@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C=C1
InChi Code
InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18-/m0/s1
InChi Key
MYHXHCUNDDAEOZ-UKUWKSPLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-10235-500 |
|---|---|
| Supplier Part Number | 10235-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 474391-66-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |