Cayman EP4 Receptor (C-Term) Polyclonal PE Antibody

Prostaglandin E₂ (PGE₂) binds to four receptor subtypes: EP₁, EP₂, EP₃, and EP₄, which are all membrane-bound G protein-coupled receptors (GPCRs).^,, The EP₄ receptor was originally classified as the EP₂ receptor but was not activated by the EP₂ agonist butaprost (Item Nos. | ) and was later found to be a distinct receptor with sequence differences.^, It is expressed in many tissues, including the intestine, heart, kidney, lungs, and brain, and is also expressed in peripheral blood leukocytes and macrophages. The EP₄ receptor is coupled to Gα_s, and its activation increases intracellular cAMP levels, leading to tissue-specific effects. It induces smooth muscle relaxation, angiogenesis, T cell expansion, osteoblast differentiation, and bone resorption and inhibits TNF-α production in monocytes and macrophages, among other activities. PTGER4, the gene encoding the EP₄ receptor, is overexpressed in a variety of cancers, and antagonism of the receptor in animal models inhibits tumor growth and angiogenesis. In contrast, EP₄ receptor activation has anti-inflammatory and neuroprotective activities in vitro and in animal models.^, Cayman’s EP₄ Receptor (C-Term) Polyclonal PE Antibody can be used for flow cytometry (FC) and immunofluorescence (IF) applications.

WARNING This product is not for human or veterinary use.