Cayman (S)-AM1241

(S)-AM1241 binds to cannabinoid (CB) receptors and is selective for the CB₂ over the CB₁ receptor (K_is = 658 and >10,000 nM, respectively, in a membrane assay using human receptors). (S)-1241 acts as an agonist at human, rat, and mouse CB₂ receptors but shows greater activity at human CB₂ (EC₅₀ = 131 nM) than at rat and mouse CB₂ receptors (EC₅₀ = 785 and 2,000 nM, respectively). Similar to the racemate AM1241 (Item No. ), (S)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing effect of (S)-AM1241 is blocked by the CB₂-specific inhibitor SR 144528 (Item No. ) but not by either the CB₁-selective inhibitor rimonabant (Item No. ) or the opioid receptor blocker naloxone (Item No. | ).

WARNING This product is not for human or veterinary use.