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Cayman Necrostatin-5
List Price $54.00 Your Price $54.00
Cayman Necrostatin-5 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10527-5
MFG.PART: 10527-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Necrostatin-5 is a RIP1 kinase inhibitor.1 It inhibits phosphorylation of RIP1 in Jurkat cells when used at concentrations of 10 and 30 µM. Necrostatin-5 inhibits TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 0.24 µM), a modification that prevents caspase activation in response to death-domain receptor signaling. It reduces lactate dehydrogenase (LDH) release in S. marcescens-infected MH-S macrophages in a concentration-dependent manner.2 Necrostatin-5 (100 µM, i.p.) improves survival in a mouse model of S. marcescens-induced pneumonia.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-
CAS Number
337349-54-9
Synonyms
- Nec-5
Molecular Formula
C19H17N3O2S2
Formula Weight
383.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- Chloroform: 10 mg/mL
- DMF: Slightly Soluble
- DMSO: Slightly Soluble
λmax
229, 324 nm
SMILES
O=C(C(C(CCCC1)=C1S2)=C2N=C3SCC#N)N3C4=CC=C(OC)C=C4
InChi Code
InChI=1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3
InChi Key
VGONMECBFMCKBS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10527-5 |
|---|---|
| Supplier Part Number | 10527-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Switzerland |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 337349-54-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |