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Cayman 3,5-dimethyl PIT-1
List Price $123.00 Your Price $123.00
Cayman 3,5-dimethyl PIT-1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10727-5
MFG.PART: 10727-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (pH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer.1 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3/Akt pH domain binding, that is designed for more favorable solubility in vivo. 3,5-dimethyl PIT-1 inhibits PI3K/Akt signaling (IC50 = 27 μM), suppressing PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 36 μM).2 4T1 breast cancer growth is significantly attenuated in BALB/c mice with a dose of 1 mg/kg of 3,5-dimethyl PIT-1 per day.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[[(2-
CAS Number
701947-53-7
Molecular Formula
C16H15N3O4S
Formula Weight
345.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 0.2 mg/mL
λmax
202, 274 nm
SMILES
O=C(NC(NC1=C(O)C=CC([N+]([O-])=O)=C1)=S)C2=CC(C)=CC(C)=C2
InChi Code
InChI=1S/C16H15N3O4S/c1-9-5-10(2)7-11(6-9)15(21)18-16(24)17-13-8-12(19(22)23)3-4-14(13)20/h3-8,20H,1-2H3,(H2,17,18,21,24)
InChi Key
CGWBCAQMXJFWBU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10727-5 |
|---|---|
| Supplier Part Number | 10727-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 701947-53-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |