We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman PIT-1
List Price $161.00 Your Price $161.00
Cayman PIT-1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-10728-50
MFG.PART: 10728-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (pH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer.1 PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP3/Akt pH domain binding with an IC50 value of 31 μM.2 PIT-1 suppresses PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM).2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[[(3-chloro-
CAS Number
53501-41-0
Molecular Formula
C14H10ClN3O4S
Formula Weight
351.8
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 0.5 mg/mL
λmax
273, 317 nm
SMILES
O=C(NC(NC1=C(O)C(Cl)=CC([N+]([O-])=O)=C1)=S)C2=CC=CC=C2
InChi Code
InChI=1S/C14H10ClN3O4S/c15-10-6-9(18(21)22)7-11(12(10)19)16-14(23)17-13(20)8-4-2-1-3-5-8/h1-7,19H,(H2,16,17,20,23)
InChi Key
RIGXBXPAOGDDIG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10728-50 |
|---|---|
| Supplier Part Number | 10728-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 53501-41-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |