Cayman SMAD3 Polyclonal Antibody

SMAD3, a member of the SMAD family of proteins, is involved in the TGF-β signaling cascade. A human homolog of Drosophila Mad protein, SMAD3 consists of an N-terminal DNA-binding MH1 domain, a linker region and a C-terminal MH2 domain. It is a receptor-regulated SMAD (R-SMAD) that functions downstream of TGF-β and activin receptors and mediates their signaling.^, It is recruited by SARA (SMAD anchor for receptor activation) to the receptor kinase for phosphorylation. Upon phosphorylation, SMAD3 dissociates from SARA, forms a complex with SMAD4 and transmigrates into the nucleus where it complexes with other cofactors and acts as a transcription factor. It has an indispensable role in cell proliferation, differentiation, apoptosis and formation of ECM. Loss of SMAD3 results in childhood T cell leukemia.

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