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Cayman CHS-828
List Price
$152.00
Your Price
$152.00
Cayman CHS-828 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-11021-10
MFG.PART:
11021-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
CHS-828 is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor (IC50 = <25 nM). It selectively inhibits Nampt over nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) at 10 µM. CHS-828 (100 nM) reduces NAD+ levels in, and is cytotoxic to, HeLa cervical cancer cells. It decreases ATP levels in C666-1 nasopharyngeal and FaDu head and neck squamous cell carcinoma (HNSCC) cells in a time-dependent manner when used at concentrations of 10 and 20 nM, respectively. CHS-828 (100 and 250 mg/kg per week) reduces tumor growth in MCF-7 breast cancer and NYH small cell lung cancer mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-
CAS Number
200484-11-3
Synonyms
- GMX 1778
Molecular Formula
C19H22ClN5O
Formula Weight
371.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/mL
- DMSO: 25 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL
- Ethanol: 0.5 mg/mL
λmax
231, 258 nm
SMILES
N#CN/C(NCCCCCCOC1=CC=C(Cl)C=C1)=N\C2=CC=NC=C2
InChi Code
InChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)
InChi Key
BOIPLTNGIAPDBY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-11021-10 |
|---|---|
| Supplier Part Number | 11021-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 200484-11-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |