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Cayman HA-155
List Price $117.00 Your Price $117.00
Cayman HA-155 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-11034-5
MFG.PART: 11034-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion. HA-155 is a boronic acid-based compound that inhibits autotaxin (IC50 = 5.7 nM) by selectively binding to its catalytic threonine.1,2 It has been shown to dose-dependently block thrombin-induced LPA secretion in platelets.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
B-[4-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid
CAS Number
1229652-22-5
Synonyms
- Autotaxin Inhibitor IV
Molecular Formula
C24H19BFNO5S
Formula Weight
463.3
Purity
≥95% (mixture of isomers)
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 50 mg/mL
- DMSO: 30 mg/mL
λmax
224, 347 nm
SMILES
FC1=CC=C(CN2C(/C(SC2=O)=C/C3=CC=C(OCC4=CC=C(B(O)O)C=C4)C=C3)=O)C=C1
InChi Code
InChI=1S/C24H19BFNO5S/c26-20-9-3-17(4-10-20)14-27-23(28)22(33-24(27)29)13-16-5-11-21(12-6-16)32-15-18-1-7-19(8-2-18)25(30)31/h1-13,30-31H,14-15H2/b22-13-
InChi Key
BRWUZCBSWABPMR-XKZIYDEJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-11034-5 |
|---|---|
| Supplier Part Number | 11034-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1229652-22-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |