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Cayman L-Kynurenine
List Price $90.00 Your Price $90.00
Cayman L-Kynurenine - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-11305-100
MFG.PART: 11305-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
L-Kynurenine is an active metabolite of tryptophan (Item Nos. | ). It is formed from tryptophan via tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to the aryl hydrocarbon receptor (AhR; Kd = ~4 µM) and increases the activity of ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50 = 12.3 µM). It decreases intracellular concentrations of NAD+ (Item No. ) in, and increases lactate dehydrogenase (LDH) activity in the supernatant of, primary human astrocytes and neurons in a concentration-dependent manner. L-Kynurenine in combination with IFN-γ reduces lung injury induced by A. fumigatus infection in the p47phox-/- mouse model of chronic granulomatous disease.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
αS,2-diamino-
CAS Number
2922-83-0
Synonyms
- 3-anthraniloyl-Alanine
- L-KYN
Molecular Formula
C10H12N2O3
Formula Weight
208.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- 0.5M HCl: 50 mg/mL
λmax
229, 257, and 370 nm
SMILES
NC1=CC=CC=C1C(C[C@H](N)C(O)=O)=O
InChi Code
InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1
InChi Key
YGPSJZOEDVAXAB-QMMMGPOBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-11305-100 |
|---|---|
| Supplier Part Number | 11305-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2922-83-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |