Cayman Oligomycin Complex

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases. The mitochondrial F₁F_O ATP synthase can switch to an ATP hydrolase during ischemia, SO that, under these conditions, inhibition by oligomycins will reduce ATP depletion rather than block ATP synthesis.¹ Oligomycin complex is a mixture of oligomycins A (Item No. 11342), B (Item No. 11343), and C. Oligomycin A is a selective inhibitor of mitochondrial F₁F_O-ATP synthase that induces apoptosis in a variety of cell types (average GI₅₀ = 270 nM).^2,3,4 Oligomycin B is a nonselective inhibitor of ATP synthases. Oligomycin B (1-10 μM) can reduce the rate of ATP depletion in myocardial ischemia and decrease calcium-induced calcium release oscillation frequency of rat sensory neurons.^1,5

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