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Cayman Tunicamycin Mixture
List Price
$43.00
Your Price
$43.00
Cayman Tunicamycin Mixture - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-11445-1
MFG.PART:
11445-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Tunicamycin mixture is a mixture of tunicamycins with variable trans-2,3-unsaturated branched chain fatty acid (BFCA) chain lengths. Tunicamycins are anti-microbial agents that are active against Gram-positive bacteria, fungi, and viruses. They inhibit the N-acetylhexosamine (HexNAc) phosphotransferase family of enzymes in bacteria and prevent peptidoglycan biosynthesis. In eukaryotes, they inhibit N-acetylglucosamine (GlcNAc) phosphotransferase (GPT), preventing the first step in N-linked glycosylation and inducing the unfolded protein response and cell death.,, The cellular toxicity of tunicamycins is linked to the trans-2,3-unsaturated BCFA, and saturated BCFA-containing tunicamycin derivatives, such as TunR1 (Item No. ) and TunR2 (Item No. ), have reduced toxicity., Tunicamycins impair glycosylation of the receptor tyrosine kinases EGFR, HER2, HER3, and IGF-1R, which prevents their translocation out of the endoplasmic reticulum and Golgi apparatus and reduces their protein levels and activity. Tunicamycin sensitizes EGFR inhibitor-resistant U251 glioma and Bx/PC-3 pancreatic adenocarcinoma cells to irradiation.
WARNING This product is not for human or veterinary use.
Technical Information
CAS Number
11089-65-9
Molecular Formula
C39H64N4O16 (for Tunicamycin VII)
Formula Weight
845.0
Purity
≥95% (mixture of congeners)
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL
λmax
208, 260 nm
SMILES
O=C1C=CN([C@@H]2O[C@H]([C@H](O)C[C@H]3O[C@@H](O[C@@H]4[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@H](NC(/C=C/CCCCCCCCCCC(C)C)=O)[C@@H](O)[C@H]3O)[C@@H](O)[C@H]2O)C(N1)=O
InChi Code
InChI=1S/C39H64N4O16/c1-20(2)14-12-10-8-6-4-5-7-9-11-13-15-25(47)41-28-32(52)29(49)23(56-38(28)59-37-27(40-21(3)45)31(51)30(50)24(19-44)57-37)18-22(46)35-33(53)34(54)36(58-35)43-17-16-26(48)42-39(43)55/h13,15-17,20,22-24,27-38,44,46,49-54H,4-12,14,18-19H2,1-3H3,(H,40,45)(H,41,47)(H,42,48,55)/b15-13+/t22-,23-,24-,27-,28-,29+,30-,31-,32-,33+,34-,35-,36-,37-,38+/m1/s1
InChi Key
ZOCXUHJGZXXIGQ-NPXWYGMKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-11445-1 |
|---|---|
| Supplier Part Number | 11445-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 11089-65-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |