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Cayman Afatinib
List Price
$51.00
Your Price
$51.00
Cayman Afatinib - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-11492-10
MFG.PART:
11492-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Afatinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 (IC50s = 0.5 and 14 nM, respectively). It increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein. Afatinib (20 mg/kg) reduces tumor growth in ErbB2-amplified NCI-N87 and NUGC4 gastric cancer mouse xenograft models. Formulations containing afatinib have been used in the treatment of non-small cell lung cancer.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2E)-N-[4-
CAS Number
850140-72-6
Synonyms
- BIBW 2992
Molecular Formula
C24H25ClFN5O3
Formula Weight
485.9
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 11 mg/mL
λmax
254, 343 nm
SMILES
N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4
InChi Code
InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
InChi Key
ULXXDDBFHOBEHA-CWDCEQMOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-11492-10 |
|---|---|
| Supplier Part Number | 11492-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 850140-72-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |