Cayman ABT-737

The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH₃ domains.¹ ABT-737 is a potent, cell-permeable mimetic of BH₃ domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (K_i < 1 nM for all three proteins).^2,3 It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis.² ABT-737, alone, can induce regression of some tumors in some xenograft mouse models of cancer.^2,1 It shows synergy with diverse therapeutics and radiation to trigger apoptosis in cancer cells and xenografts.^2,4,5

WARNING This product is not for human or veterinary use.