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Cayman Gemcitabine
List Price $301.00 Your Price $301.00
Cayman Gemcitabine - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-11690-100
MFG.PART: 11690-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 (Item No. 9003247) and gemcitabine elaidate (Item No. 28303) and a prodrug form of gemcitabine di- and triphosphates.1,2,3 Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate (Item No. 31726) and the active di- and triphosphate forms.3 It is cytotoxic to HepG2 hepatocellular carcinoma and A549 non-small cell lung cancer (NSCLC) cells (IC50s = 5.2 and 16 nM, respectively) and inhibits tumor growth in various breast, colon, lung, and pancreatic cancer mouse xenograft models.4 Gemcitabine (12 mg/kg) sensitizes tumors to antibodies targeting programmed cell death protein 1 (PD-1), decreases the number of tumor-infiltrating regulatory T cells (Tregs), and increases survival in an MC-38 syngeneic mouse model of colon carcinoma.5 Formulations containing gemcitabine have been used in the treatment of cancer.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-
CAS Number
95058-81-4
Synonyms
- DDFC
- dFdC
- LY 188011
- NSC 613327
Molecular Formula
C9H11N3O4F2
Formula Weight
263.2
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 0.1 mg/mL
- DMSO: 5 mg/mL
- Ethanol: 0.2 mg/mL
- PBS (pH 7.2): 1 mg/mL
λmax
243, 269 nm
SMILES
O=C1N=C(N)C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2
InChi Code
InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1
InChi Key
SDUQYLNIPVEERB-QPPQHZFASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-11690-100 |
|---|---|
| Supplier Part Number | 11690-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 95058-81-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |