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Cayman Demethylwedelolactone
List Price $75.00 Your Price $75.00
Cayman Demethylwedelolactone - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-11703-1
MFG.PART: 11703-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Demethylwedelolactone (DWL) is a coumestan, originally isolated from E. alba, with diverse biological activities.,,, It reduces cytotoxicity induced by CCL4 and galactosamine (GaIN; Item No. ) in rat hepatocytes in a dose-dependent manner. DWL inhibits trypsin with an IC50 value of 3.0 μg/mL in vitro. It is the major constituent in purified butanolic extracts of E. prostrata which inhibit lethal and hemorrhagic activities of C. rhodostoma venom. DWL also inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells and decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,3,8,9-
CAS Number
6468-55-9
Synonyms
- DWL
- Norwedelolactone
- 1,3,8,9-Tetrahydroxycoumestan
Molecular Formula
C15H8O7
Formula Weight
300.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 20 mg/mL
λmax
211, 250, 304, 354 nm
SMILES
OC1=CC2=C(OC(C(C(O)=CC(O)=C3)=C3O4)=C2C4=O)C=C1O
InChi Code
InChI=1S/C15H8O7/c16-5-1-9(19)13-11(2-5)22-15(20)12-6-3-7(17)8(18)4-10(6)21-14(12)13/h1-4,16-19H
InChi Key
LUTYTNLPIUCKBJ-UHFFFAOYSA-N
Origin
Plant/Eclipta alba
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-11703-1 |
|---|---|
| Supplier Part Number | 11703-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 6468-55-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |