Cayman Isoforskolin

Isoforskolin is a naturally occurring diterpene originally isolated from the Indian coleus plant C. forskohlii. It demonstrates positive inotropic effects ex vivo in guinea pig atria (EC₅₀ = 1.09 μM). In vivo, isoforskolin is antihypertensive, decreasing systolic blood pressure by 28 mmHg in spontaneously hypertensive rats when administered at 25 mg/kg per day, p.o. for 5 days. Pretreatment of rats with isoforskolin (10 mg/kg, i.p.) decreases LPS-induced lung injury by decreasing karyocyte, neutrophil count, and protein content in bronchoalveolar lavage fluid, and ameliorating LPS-induced lung morphological changes. Isoforskolin (1 mg/kg, i.p.) decreases mean arthritis index in a mouse model of Lyme arthritis induced by injection of B. burgdorferi basic membrane protein A (BmpA) into the tibiotarsal joint cavity. Isoforskolin also activates membranous mammalian adenylyl cyclase (AC) expressed in insect cells (EC₅₀s = 0.8, 13.3, and 7.4 μM for AC1, AC2, and AC5, respectively).

WARNING This product is not for human or veterinary use.