Cayman 24α-ethyl Cholesterol (technical grade)

24α-ethyl Cholesterol is a phytosterol that has been found in S. plebia and has diverse biological activities.^1,2,3,4,5 It protects lard from thermal oxidation when used at concentrations of 0.02 and 0.04%.¹ 24α-ethyl Cholesterol (100 µM) induces glucose uptake and lipolysis in primary rat differentiated adipocytes and adipogenesis in primary rat preadipocytes.² It is cytotoxic to MCF-7 breast cancer cells (IC₅₀ = 264.83 µM).³ 24α-ethyl Cholesterol increases protein levels of the glucocorticoid receptor in TGF-β1-induced human bronchial smooth muscle cells and prevents pulmonary fibrosis in a mouse model of allergic asthma induced by ovalbumin.⁴ Dietary administration of 24α-ethyl cholesterol (0.5%) reduces cholesterol-induced increases in liver weight and hepatic levels of cholesterol (Item No. 9003100) in rabbits.⁵ 24α-ethyl Cholesterol has also been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.⁶ Formulations containing 24α-ethyl cholesterol have been used as dietary supplements.

WARNING This product is not for human or veterinary use.