Cayman HC-030031

Transient receptor potential cation channel A₁ (TRPA1) is an ankyrin-like ion channel which acts as a sensor for chemical irritants, pain, and cold. It is activated by allyl isothiocyanate (AITC), formalin, hydrogen peroxide, tear gas, and other compounds.^1,2,3 HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC₅₀s = 6.2 and 5.3 μM, respectively).² It does not block currents mediated by TRPV1, TRPV3, TRPV4 hERG, or Na_V1.2 channels.² HC-030031 can be used in cells or delivered to animals orally, by inhalation, or by injection.^2,4,5,6 Oral administration (100 mg/kg) of HC-030031 significantly reversed mechanical hypersensitivity in rat models of chronic inflammatory or neuropathic pain, while local injection (100 μg) into inflamed mouse hind paws attenuated mechanical, but not heat, hypersensitivity.^4,6

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