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Cayman SR 58611A (hydrochloride)
List Price $66.00 Your Price $66.00
Cayman SR 58611A (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-11954-1
MFG.PART: 11954-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SR 58611A is a selective β3-adrenergic receptor agonist (β3-AR; EC50 = 3.5 nM in rat colon). Its activity cannot be blocked by the β1- and β2-AR antagonists CGP 20712A and ICI 118551 (Item No. ), respectively. SR 58611A is minimally active against β1-ARs in rat uterus (EC50 = 499 nM) and inactive against β2-ARs in guinea pig trachea and atrium (EC50s = >10,000 and >30,000 nM, respectively). SR 58611A activates brown fat metabolism through activation of adenylyl cyclase activity and glycerol release in brown adipocytes (EC50s = 20 and 11 nM, respectively). It also reduces hypothermia produced by apomorphine (Item No. ) and reserpine (Item No. ) and potentiates toxicity produced by yohimbine (Item No. ) in mice. SR 58611A (0.6 to 2 mg/kg/day) also reduces the number of escape failures in a learned helplessness model of antidepressant-like activity in rats without changes in locomotor activity typically seen with β2-AR agonists.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[[(7S)-7-[[(2R)-
CAS Number
121524-09-2
Synonyms
- Amibegron
Molecular Formula
C22H26ClNO4 • HCl
Formula Weight
440.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 30 mg/mL
λmax
277 nm
SMILES
CCOC(COC1=CC=C(CC[C@H](NC[C@H](O)C2=CC(Cl)=CC=C2)C3)C3=C1)=O.Cl
InChi Code
InChI=1S/C22H26ClNO4.ClH/c1-2-27-22(26)14-28-20-9-7-15-6-8-19(11-17(15)12-20)24-13-21(25)16-4-3-5-18(23)10-16;/h3-5,7,9-10,12,19,21,24-25H,2,6,8,11,13-14H2,1H3;1H/t19-,21-;/m0./s1
InChi Key
NQIZCDQCNYCVAS-RQBPZYBGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-11954-1 |
|---|---|
| Supplier Part Number | 11954-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 121524-09-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |