Cayman AMD 3465 (hydrobromide)

C-X-C chemokine receptor type 4 is a receptor for the stromal cell-derived factor-1 which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis.^,, AMD 3465 blocks the cell surface binding of CXCL12 with an IC₅₀ value of 18 nM. It inhibits CXCL12-induced calcium mobilization (IC₅₀ = 4 nM) and at 6,250 nM completely blocks CXCL12-induced chemotaxis of SupT1 cells. AMD 3465 is active against various HIV strains with IC₅₀ values ranging from 6 to 12 nM. It dose dependently inhibits eosinophil recruitment during type-2 granuloma formation and interferes with primary and secondary T-cell activation events in lymphoid tissue. At 50 μg/day, AMD 3465 blocks tumor growth and prevents CXCL12-induced cAMP suppression in xenograft models of medulloblastoma and glioblastoma.

WARNING This product is not for human or veterinary use.