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Cayman SR 2211
List Price $178.00 Your Price $178.00
Cayman SR 2211 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-11972-10
MFG.PART: 11972-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Retinoic acid receptor-related nuclear receptor γ (RORγ) plays a central role in T cell differentiation, particularly in the differentiation of pro-inflammatory TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis.1,2 SR 2211 selectively binds RORγ (Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORγ activity (IC50 = 320 nM).3 It has minimal effects on RORα, LXRα, and FXR activities. SR 2211 significantly inhibits gene expression of IL-17 and IL-23 receptor in activated EL-4 mouse T lymphocytes when given at 5 μM.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-fluoro-4’-
CAS Number
1359164-11-6
Molecular Formula
C26H24F7N3O
Formula Weight
527.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 10 mg/mL
λmax
251 nm
SMILES
OC(C(F)(F)F)(C1=CC(F)=C(C2=CC=C(CN3CCN(CC4=CC=NC=C4)CC3)C=C2)C=C1)C(F)(F)F
InChi Code
InChI=1S/C26H24F7N3O/c27-23-15-21(24(37,25(28,29)30)26(31,32)33)5-6-22(23)20-3-1-18(2-4-20)16-35-11-13-36(14-12-35)17-19-7-9-34-10-8-19/h1-10,15,37H,11-14,16-17H2
InChi Key
KVHKWAZUPPBMLL-UHFFFAOYSA-N
License
Sold under license from The Scripps Research Institute.
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-11972-10 |
|---|---|
| Supplier Part Number | 11972-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 1359164-11-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |