Cayman Ro 67-4853

Ro 67-4853 is a positive allosteric modulator of metabotropic glutamate 1 receptors (mGluR1), enhancing glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors (pEC₅₀ = 7.16).^1,2 While only mildly potentiating mGluR5 signaling, this compound is without effect at mGluR2, mGluR4, or mGluR8, as well as at several other neural receptors.¹ Ro 67-4853 can also directly activate mGluR1 signaling in baby hamster kidney cells, leading to phosphorylation of ERK1/2 (EC₅₀ = 6.2 nM) and activation of adenylate cyclase (EC₅₀ = 11.7 μM).³ Ro 67-4853 can also be used to enhance neuronal stimulation in response to the mGluR1/mGluR5 agonist DHPG, both in vivo and in vitro (EC₅₀ = 95 nM).^1,4

WARNING This product is not for human or veterinary use.