Cayman CysLT2 Receptor (C-Term) Polyclonal Antibody

The cysteinyl leukotrienes (cysLTs; LTC₄, LTD₄, and LTE₄) contract airway and pulmonary vascular smooth muscle, increase vascular permeability, and stimulate mucus secretion, thereby playing a major role in asthma.^,,, LTC₄, LTD₄, and LTE₄ mediate their actions via at least two receptors designated CysLT₁ and CysLT₂. Cloning of the human CysLT₂ receptor reveals it is a 346 amino acid protein with 38% homology to the CysLT₁ receptor.^, The rank order of binding for leukotrienes to the cloned receptor, as determined using a radioligand binding assay, is LTC₄ = LTD₄ >> LTE₄. The mRNA for the human CysLT₂ receptor is expressed in lung macrophages, airway smooth muscle, cardiac Purkinje cells, adrenal medulla cells, peripheral blood leukocytes, spleen, placenta, and brain.^,

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