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Cayman SR 1555 (hydrochloride)
List Price
$445.00
Your Price
$445.00
Cayman SR 1555 (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-12071-25
MFG.PART:
12071-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Retinoic acid receptor-related nuclear receptor γ (RORγ) plays a central role in T cell differentiation, particularly in the development of TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis.1,2 SR 1555 is a selective ligand of RORγ (IC50 = 1 μM).3 It does not bind RORα, LXR, or FXR. SR 1555 acts as an inverse agonist of RORγ, inhibiting endogenous IL-17A gene expression in mouse splenocytes and suppressing differentiation of TH17 cells when cultured under TH17 polarizing conditions.3 Moreover, SR 1555 stimulates T regulatory development when cultured under T regulatory polarizing conditions, unlike digoxin and ursolic acid.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[4-[[4-
CAS Number
2309312-90-9
Molecular Formula
C22H22F6N2O2 • HCl
Formula Weight
496.9
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 5 mg/mL
- DMF:PBS (pH 7.2) (1:6): 0.16 mg/mL
- DMSO: 3 mg/mL
- Ethanol: 1.6 mg/mL
λmax
203, 257 nm
SMILES
O=C(C)N(CC1)CCN1CC2=CC=C(C3=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C3)C=C2.Cl
InChi Code
InChI=1S/C22H22F6N2O2.ClH/c1-15(31)30-12-10-29(11-13-30)14-16-2-4-17(5-3-16)18-6-8-19(9-7-18)20(32,21(23,24)25)22(26,27)28;/h2-9,32H,10-14H2,1H3;1H
InChi Key
OHUOFZJUUXXRGG-UHFFFAOYSA-N
License
Sold under license from The Scripps Research Institute.
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-12071-25 |
|---|---|
| Supplier Part Number | 12071-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2309312-90-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |