We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman 17(R)-Resolvin D1
List Price
$758.00
Your Price
$758.00
Cayman 17(R)-Resolvin D1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-13060-50
MFG.PART:
13060-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).1 In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.2 Resolvin D1 (RvD1; Item No. 10012554) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.1 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM).3 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.3 In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
7S,8R,17R-
CAS Number
528583-91-7
Synonyms
- Aspirin-triggered Resolvin D1
- AT-RvD1
- 17-epi-Resolvin D1
- 17(R)-RvD1
Molecular Formula
C22H32O5
Formula Weight
376.5
Purity
≥95%
Formulation(Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
- DMF: 50 mg/mL
- Ethanol: 50 mg/mL
- PBS (pH 7.2): 0.05 mg/mL
λmax
302 nm
SMILES
CC/C=C\C[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O
InChi Code
InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20-,21+/m1/s1
InChi Key
OIWTWACQMDFHJG-BJEBZIPWSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Stability
≥ 1 year
| SKU | CAYM-13060-50 |
|---|---|
| Supplier Part Number | 13060-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -80 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 528583-91-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |