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Cayman Tenovin-1
List Price $488.00 Your Price $488.00
Cayman Tenovin-1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-13085-100
MFG.PART: 13085-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells.1 Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD+-dependent class III histone deacetylases that belong to the sirtuin family.1 While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[[[4-
CAS Number
380315-80-0
Molecular Formula
C20H23N3O2S
Formula Weight
369.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 0.50 mg/mL
- DMSO: 0.25 mg/mL
λmax
274 nm
SMILES
CC(=O)Nc1ccc(cc1)NC(=S)NC(=O)c1ccc(cc1)C(C)(C)C
InChi Code
InChI=1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26)
InChi Key
WOWJIWFCOPZFGV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13085-100 |
|---|---|
| Supplier Part Number | 13085-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 380315-80-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |