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Cayman PA-824
List Price $41.00 Your Price $41.00
Cayman PA-824 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-13142-1
MFG.PART: 13142-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PA-824 is an anti-tuberculosis (anti-TB) agent that is activated intracellularly via deazaflavin-dependent nitroreductase (Ddn) metabolism into a desnitro metabolite that kills M. tuberculosis by releasing reactive nitrogen species (RNS), including nitric oxide. It is active against replicating and non-replicating M. tuberculosis but exhibits little or no activity against M. avium, M. smegmatis, M. chelonae, and M. fortuitum. In vitro, it inhibits growth of susceptible and mono- and multi-drug resistant M. tuberculosis clinical isolates (MICs = 0.015-5 μg/mL)., In vivo, PA-824 (100 mg/kg per day) decreases luminescence in the lung to background levels after 60 days of treatment in a mouse model of systemic infection with a reporter strain of M. tuberculosis. It also decreases M. tuberculosis burden in the lung and spleen in an aerosol challenged guinea pig model of TB when administered at a dose of 40 mg/kg per day for 30 days.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(6S)-6,7-
CAS Number
187235-37-6
Synonyms
- (S)-PA-824
Molecular Formula
C14H12F3N3O5
Formula Weight
359.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 33 mg/mL
- DMSO: 33 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL
- Ethanol: 5 mg/mL
λmax
324 nm
SMILES
FC(F)(F)OC1=CC=C(CO[C@@H]2COC3=NC([N+]([O-])=O)=CN3C2)C=C1
InChi Code
InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1
InChi Key
ZLHZLMOSPGACSZ-NSHDSACASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13142-1 |
|---|---|
| Supplier Part Number | 13142-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 187235-37-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |